相关实验视频
Updated: Feb 7, 2026

08:39
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
5.5K
膀癌免疫治疗的进展以及下一代测序的临床实践
Wei Ning1, Pengkang Chang1, Ji Zheng1
1Department of Urology, Urologic Surgery Center, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Frontiers in immunology
|February 6, 2026
概括
膀癌治疗的进步包括下一代测序,以获得分子洞察力和向治疗. 免疫检查点抑制剂对特定的膀癌亚型有前途,改善了患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 膀癌是全球重要的健康负担,晚期的治疗选择有限.
- 几十年来,基于的化疗一直是标准的,但耐药性和毒性仍然是挑战.
- 基因组学的最新进展改善了我们对膀癌分子格局的理解.
研究的目的:
- 审查最近膀癌治疗策略的进展.
- 突出下一代测序在了解膀癌中的作用.
- 总结关键的分子特征和未来的治疗方向.
主要方法:
- 审查关于膀癌治疗的当前文献.
- 分析下一代测序数据用于分子表征.
- 对免疫疗法和向药物的临床试验数据的评估.
主要成果:
- 下一代测序揭示了具有高突变负担和微卫星不稳定的膀癌亚型.
- 免疫检查点抑制剂在特定患者群体中显示出有效性.
- 包括FGFR抑制剂和抗体-药物合物在内的向疗法正在出现.
结论:
- 精准医学方法,以分子分析为指导,正在改变膀癌治疗.
- 免疫疗法和向疗法为患有晚期或转移性疾病的患者提供了新的希望.
- 对分子亚型的持续研究将推动新型治疗策略的开发.
相关概念视频
Next-generation Sequencing
98.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
98.6K
Tumor Immunotherapy
2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Urinary Bladder
3.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.5K
Overview of Advanced Functional Groups
30.1K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K
Characteristics of Practical Op Amps
870
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
870
Theoretical Foundations of Nursing Practice
17.5K
Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
17.5K

