探索不同DNA修复蛋白在短反转重复中介基因组不稳定性中的作用:试点研究

Pooja Mandke1, Karen M Vasquez1

  • 1Dell Pediatric Research Institute, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USA.

DNA
|February 6, 2026
PubMed
概括

与Z-DNA和H-DNA不同的是,十字形DNA结构不依赖于不匹配或核酸切除修复途径进行处理. 相反,核酶CtIP和MRE11积极抑制由这些结构引起的基因组不稳定性.

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