一个随机,双盲,安慰剂控制的可溶性玉米纤维补充剂对患有喘的儿童的随机,双盲,安慰剂控制的试验
Matthew A Rank1,2, Daisy L Barroso3, Kathryn A Conn3
1Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic in Arizona, Scottsdale, AZ, United States.
Frontiers in allergy
|February 6, 2026
概括
食纤维补充剂对儿童的喘症状或肠道微生物组变化的影响很小. 需要进一步的研究来探索更高的纤维剂量和个人对潜在益处的反应.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 喘是一种复杂的呼吸道疾病,受遗传学和环境的影响,包括饮食.
- 肠道微生物组通过肠肺轴和短链脂肪酸 (SCFA) 生产在呼吸道炎症中发挥作用.
- 肠道细菌的食纤维发酵会影响SCFA水平和免疫反应.
研究的目的:
- 研究可溶性玉米纤维 (SCF) 补充剂对喘儿童肠道微生物群和SCFA水平的影响.
- 评估食纤维对喘控制和症状的影响.
主要方法:
- 一项双盲,安慰剂对照试验,涉及儿童每天补充12g的SCF或安慰剂,持续4-6周.
- 收集饮食调查,喘问卷,便,血液和鼻腔样本进行分析.
- 量化纤维摄入量,控制喘,微生物组合和血清SCFA.
主要成果:
- 在20名儿童中,有15名儿童完成了这项研究,其遵守率为83%.
- 对于SCFA度和微生物组合的个体反应有所不同.
- 没有观察到肠道或鼻腔微生物群多样性的显著变化;在SCF组中发现了增加*Bifidobacterium*的趋势.
结论:
- 在这个队列中,补充50%的建议每日纤维摄入量对喘症状,微生物组或SCFA水平的影响有限.
- 个体反应的变化表明在未来的研究中需要更高的纤维剂量,不同的纤维类型或有针对性的干预措施.
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