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相关概念视频

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

10.6K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
10.6K
Preparation of Samples for Electron Microscopy01:20

Preparation of Samples for Electron Microscopy

7.2K
To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...
7.2K
Voltage01:13

Voltage

4.3K
The movement of electrons in a conductor requires some form of energy or work, usually provided by an external force, like a battery. This force is called the electromotive force or voltage. The voltage between two points, referred to as points "a" and "b," in an electric circuit is the energy (or work) needed to move a unit charge from point "a" to point "b," and this relationship is expressed mathematically as
4.3K
Multiple Voltage Sources01:25

Multiple Voltage Sources

1.8K
Generally, a single battery is not enough to power some devices. In such cases, batteries can be combined in two ways: in series or in parallel.
In series, the positive terminal of one battery is connected to the negative terminal of another battery. Hence, the voltage of each battery is added to give the net voltage, which is increased because each battery boosts the electrons that enter it. The same current flows through each battery because they are connected in series.
Batteries are...
1.8K
Voltage Dividers01:14

Voltage Dividers

1.4K
In electrical circuits, resistors can be connected in series, sequentially linked one after the other. In a series configuration, the same current flows through each resistor. Ohm's law is a fundamental principle to understand the behavior of resistors in series. It expresses the voltage across these resistors in terms of the current and resistance.
Kirchhoff's voltage law implies that the sum of the voltages across the resistors in series equals the source voltage. This means that the current...
1.4K
Three-Phase Voltages01:30

Three-Phase Voltages

592
A three-phase generator produces three voltages that are equal in magnitude but have a phase difference of 120 degrees. This identical magnitude and equal phase separated voltages are known as the balanced voltages and help to minimize power loss while ensuring a steady delivery of energy to connected loads. As voltage sources in a three-phase system can be configured in a wye or a delta formation, the loads connected to these systems can also be arranged in either configuration. This...
592

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相关实验视频

Updated: Feb 7, 2026

Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy
11:15

Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy

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时间采样在电压成像显微镜中的含义

Jakub Czuchnowski, Jerome Mertz

    ArXiv
    |February 6, 2026
    PubMed
    概括

    电压成像显微镜使用不同的采样方法. 扫描显微镜在低信号噪声方面表现出色,而广场显微镜在低样本数据方面更好,指导最佳参数选择.

    科学领域:

    • 神经科学是一个神经科学.
    • 在光学成像系统中,光学成像
    • 生物物理学的生物物理.

    背景情况:

    • 电压成像显微镜对于研究神经活动至关重要.
    • 有各种各样的显微镜技术,包括扫描和广场.
    • 时间采样对信号忠实性的影响仍未得到充分研究.

    研究的目的:

    • 在扫描和广场显微镜中分析时间采样.
    • 评估采样对电压峰值检测准确性的影响.
    • 为优化电压成像参数提供指导.

    主要方法:

    • 开发了一个数学框架.
    • 使用分析建模和蒙特卡洛模拟.
    • 在不同条件下比较性能.

    主要成果:

    • 扫描显微镜在低信号噪声比率和检测稀疏尖峰方面优越.
    • 广场显微镜在时间下面采样和高峰检测分数方面表现更好.
    • 在高率与指标衰减相匹配的高率下,性能趋同.

    结论:

    • 为在电压成像中选择最佳时间采样提供指导.

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  • 建议不要使用扫描电压成像低于500Hz的率.