使用45毫米长的神经像素探针进行高密度多深度人体记录
ArXiv
|February 6, 2026
概括
神经像素探头,最初是用于动物,现在安全地用于人类脑部手术. 这项技术允许在手术期间同时从多个大脑区域进行高分辨率的神经记录.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 医疗技术 医疗技术 医学技术
背景情况:
- 神经像素探测器通过在动物模型中实现高密度,单细胞分辨率记录来彻底改变神经科学.
- 神经像素1.0 NHP长探头将这种能力扩展到非人类灵长类动物,访问多个皮质层和深层大脑结构.
研究的目的:
- 报告Neuropixels探针在人类的首次手术内使用.
- 为了确定这些探针的安全性和可行性,用于神经外科的临床和研究应用.
主要方法:
- 纳入了接受神经外科手术 (/瘤切除,DBS植入) 的9名患者.
- 神经像素 1.0 NHP 长探头在手术内部署用于神经记录.
- 开发了定制工具和精细的工作流程,以促进操作使用和提高记录稳定性.
主要成果:
- 从人体表面和深层皮质结构中获得了成功的手术内记录,没有不良事件或探针断裂.
- 神经像素探测器能够在多个深度进行密集采样,具有亚毫秒时间分辨率,超过传统电极.
- 在单个神经元分辨率下,记录捕捉了来自深层目标 (海马体,环状皮质) 和具有挑战性的区域 (上额叶) 的神经活动.
结论:
- 神经像素 1.0-NHP 长探头可以安全地部署在人体手术室,同时进行高分辨率的神经记录.
- 这项技术显著扩大了人类大脑功能和病理学的体内研究机会.
- 这些发现可能有助于开发更精确的神经外科干预措施.
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