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一种新的lanostane类型的三烯,具有Ganoderma lucidum的降脂活性,以及额外的类似物

Xuesheng Hu¹, Lu Han¹, Yiying Tan¹

¹Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.

Frontiers in chemistry

|February 6, 2026

概括

研究人员发现了两种新的Ganoderma三烯,可以减少肝脏脂肪的积累. 化合物2在非酒精性脂肪性肝病 (NAFLD) 的体外模型中显示出优异的降脂效应.

科学领域:

药理学和天然产品化学化学
肝病学和代谢疾病

背景情况:

非酒精性脂肪性肝病 (NAFLD) 是一种普遍存在的慢性肝病,其特点是肝脂积累,氧化应激和炎症.
传统中医药中的"光" (Ganoderma lucidum) 已因其潜在的肝脏保护作用而闻名.

研究的目的:

从Ganoderma lucidum中分离和识别新的生物活性化合物,这些化合物有潜力减轻肝脏脂肪积累.
用NAFLD的体外模型评估分离化合物的降脂功效.

主要方法:

通过使用油酸诱导的HepG2细胞建立了体外肥胖症模型.
利用色谱技术进行化合物隔离和1D/2DNMR光谱用于结构阐明.
评估了总甘油三 (TG) 含量和治疗细胞中的脂质积累抑制.

主要成果:

成功分离了十个Ganoderma三烯,其中包括两种新型的lanostane型三烯 (化合物1-2).
化合物1-5在油酸诱导的HepG2细胞模型中显示出TG水平的显著降低.
与化合物1和阳性对照药物相比,化合物2表现出明显优异的降脂效果.

结论:

从Ganoderma lucidum中确定了两种新的lanostane类型的三烯,它们对NAFLD具有潜在的治疗价值.
化合物2显示显著的承诺作为一个强大的药物来减少肝脏脂质积累.
目前正在进行进一步的研究,包括网络药理学和分子模拟,以阐明作用机制.

关键词:

这种植物叫做Ganoderma lucidum.甘树三烯的三烯.在HepG2细胞中,HepG2细胞这是NAFLD.脂质的积累脂质的积累

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