美国短肠综合征相关肠衰竭患者的流行病学:一个索赔数据库分析
Ahan Ali1, Gail Mitchell2, Mark Gallivan1
1Trinity Life Sciences, Waltham, MA, USA.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
概括
在美国,短肠综合征相关肠衰竭 (SBS-IF) 的患病率从2019年到2021年增加了超过24%. 在2021年,大约有12,000人患有SBS-IF,这突显了日益严重的公共卫生问题.
科学领域:
- 胃肠病学和肝病学
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 短肠综合征 (SBS) 导致肠切除后的吸收不良和潜在的肠衰竭 (IF),通常需要亲肠支 (PS).
- 以往使用保险索赔的流行病学研究缺乏诊断特异性,可能导致患者错误分类.
- 最近的ICD-10代码为SBS和IF提供了更好的识别,使得更准确的流行率估计成为可能.
研究的目的:
- 确定美国每年依赖PS的SBS相关肠衰竭 (SBS-IF) 患者的患病率.
- 使用更新的诊断代码和索赔数据,从2019年到2021年来描述SBS-IF的流行情况.
- 为未来的卫生服务和研究分析提供当代的流行病学数据.
主要方法:
- 来自科莫多医疗保健地图TM数据库 (2019-2021) 的索赔数据的回顾性分析.
- 患者鉴定标准包括:≥2个慢性/持续营养要求 (间隔≥6个月),吸收不良的诊断,以及胃肠道手术或先天性肠道疾病的病史.
- 每年患病率是使用预测到美国人口的年龄和性别的队列诊断率来计算的.
主要成果:
- 在2021年,美国SBS-IF的估计点患病率为约12,000人 (每百万人口约36人).
- 在整个研究期间,患病率在性别 (2/3女性) 和年龄分布方面保持稳定.
- 从2019年到2021年,SBS-IF患病率增加了超过24%;敏感性分析表明,上限接近30,000人.
结论:
- 基于索赔的算法结合了持续的PS和临床有效性信号,准确地估计了SBS-IF的患病率.
- 该研究提供了对SBS-IF.的一致和当代美国患病率估计.
- 这些发现支持对SBS-IF的进一步流行病学和卫生服务研究.
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