新生儿开始肠衰竭的发生率,预测因素和结果
Rishi Bolia1, Shay McLaren1, Sara Alremawi1
1Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, Brisbane, Australia.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
概括
新生儿肠衰竭 (IF) 和短肠综合征 (SBS) 影响每10万活产婴儿分别为13.7和10.51. 大多数患有IF的婴儿都能获得肠道自主,小肠的剩余长度是成功的关键预测指标.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 新生儿手术 新生儿手术
- 临床流行病学 临床流行病学
背景情况:
- 新生儿开始的肠衰竭 (IF) 和短肠综合征 (SBS) 是新生儿发病的重要原因.
- 了解这些疾病的发病率,预测因素和结果对于改善患者护理至关重要.
研究的目的:
- 估计澳大利亚昆士兰州新生儿IF和SBS的基于人口的发病率.
- 确定与新生儿IF发展相关的临床预测因素.
- 确定新生儿IF和SBS的婴儿的结果,包括实现肠道自主性.
主要方法:
- 对从2018年4月至2022年3月入住昆士兰儿童医院的婴儿进行了回顾性审查,这些婴儿在新生儿期需要肠道营养 (PN).
- 肠道衰竭 (IF) 被定义为由于胃肠道原因需要PN超过60天.
- 基于人口的发病率是使用国家人口普查数据来计算的.
主要成果:
- 每10万活产婴儿中IF的发病率为13.7,每10万活产婴儿中SBS-IF的发病率为10.51.
- 与没有FI的婴儿相比,患有FI的婴儿的出生体重,妊娠年龄和小肠残留长度明显较低.
- 独立预测IF的因素包括较短的小肠残留长度和缺失结肠. 71%的IF患者实现了肠道自主,没有死亡率.
结论:
- 新生儿IF和SBS-IF在昆士兰州的发病率很高.
- 大多数新生儿IF的婴儿可以实现肠道自主,小肠的剩余长度是关键预测因素.
- 预测因素的早期识别和主动管理可以改善FI和SBS的婴儿的结果.
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