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患有慢性肠衰竭的儿童感染性内心炎
Divya Pandey1, Veena Logarajah1, Lay Queen Ng1
1Gastroenterology, Hepatology & Nutrition, Paediatric Medicine, KK Women's and Children's Hospital, Singapore.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
概括
传染性内心炎 (IE) 是患有肠衰竭 (IF) 的儿童罕见的风险,需要通过肠道营养 (PN). 建议对高风险儿科IF患者进行早期心脏监测,以确保及时诊断和干预.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 传染性内心炎 (IE) 是患有慢性肠衰竭 (IF) 的儿科患者的一种严重并发症.
- 患有IF的患者通常需要通过中央静脉接入装置 (CVAD) 进行长期肠道营养 (PN),从而增加IE风险.
- 这项研究研究了单一机构中FI儿童的IE发病率,临床特征和结局.
研究的目的:
- 确定患有慢性肠衰竭 (IF) 的儿科患者感染性内心炎 (IE) 的发生率,这取决于长期的亲肠营养 (PN).
- 描述IE在这个高风险儿科群体中的临床特征和结果.
- 评估IE与导管持续时间,血液感染和静脉血栓形成等因素之间的关联.
主要方法:
- 在2013年至2024年期间,对儿科患者 (0-18岁) 进行了一项回顾性描述性研究,该研究涉及慢性IF患者,在60天以上的时间内需要PN.
- 感染性内心炎 (IE) 诊断使用修改的杜克标准得到证实.
- 收集和分析了有关患者特征,IE发作,治疗和结果的数据.
主要成果:
- 在29名儿科IF患者中,有4人发生了5次IE发作,整体发病率为0.144/1000个导管日.
- 与没有IE的患者相比,IE患者的导管持续时间显著更长,中线相关的血液感染更多,与导管相关的静脉血栓的患病率更高.
- 所有的IE病例都通过抗菌药物治疗得到解决;结果包括一个因并发症而死亡,一个患者实现了肠道自主,以及两个成功的肠道移植.
结论:
- 传染性内心炎 (IE) 虽然不常见,但对于患有肠衰竭 (IF) 的儿科患者来说,存在重大风险.
- 诸如长时间使用中央静脉接入装置 (CVAD),中枢线相关的血液感染和静脉血栓形成等因素与此群体的IE有关.
- 高风险儿科IF患者的早期心脏监测对于及时诊断和干预至关重要,可能改善结果.
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