Allium saralicum M. Fritsch 提取物改善了雄性大鼠的认知功能,这些大鼠患有链毒素诱导的糖尿病认知障碍
Shima Mohammadi1,2, Leila Karimi-Zandi3,4, Parviz Dousti Kataj5
1Department of Neurosciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Avicenna journal of phytomedicine
|February 6, 2026
概括
在糖尿病老鼠模型中,Allium saralicum M. Fritsch (ASRMF) 提取物改善了记忆,减少了炎症. 这表明ASRMF对与糖尿病相关的认知衰退具有治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病 (DM) 显著增加精神疾病和认知能力下降的风险.
- (Allium saralicum M. Fritsch) (ASRMF) 具有已知的抗氧化,抗炎和神经保护性质.
- 链毒素 (STZ) 诱导的糖尿病是研究认知功能障碍的常见模型.
研究的目的:
- 评估ASRMF在缓解STZ诱导的糖尿病大鼠模型中的记忆障碍方面的疗效.
- 评估ASRMF对胰岛素类生长因子1 (IGF-1) 表达和炎症标志物的影响.
- 在与糖尿病相关的认知功能障碍的背景下探索ASRMF的神经保护机制.
主要方法:
- 使用STZ (60毫克/公斤) 诱导男性Wistar大鼠患上糖尿病.
- 动物每天口服ASRMF提取物 (250毫克/公斤) 15天.
- 使用莫里斯水迷宫 (MWM) 评估空间学习和记忆,通过免疫组织化学分析IGF-1和NF-κB水平的大脑组织.
主要成果:
- 在糖尿病大鼠中,ASRMF治疗显著提高了空间学习和记忆性能.
- 在海马体中观察到IGF-1表达的显著增加和NF-κB水平的下降.
- 服用ASRMF与改善血糖控制相关.
结论:
- 在糖尿病老鼠认知功能障碍模型中,ASRMF显示出显著的神经保护作用.
- 似乎ASRMF的抗炎性质在它的治疗作用中起着关键作用.
- 建议进行进一步的研究,以充分阐明ASRMF神经保护益处的机制.
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