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骨科足手术中的抗脂综合征:一种倾向匹配分析
Kush Mody1, Avani A Chopra2, Michael Greenberg1
1Rutgers New Jersey Medical School, Newark, NJ, USA.
Foot & ankle orthopaedics
|February 6, 2026
概括
接受足手术的抗脂综合征 (APS) 患者面临更高的血栓风险,即使使用预防性抗凝药. 然而,抗凝药也导致这些患者的贫血率降低.
科学领域:
- 整形外科手术 整形外科手术
- 类风湿病学 类风湿病学
- 血管外科 血管外科
背景情况:
- 抗脂综合征 (APS) 是一种自身免疫性疾病,增加了血凝块 (血栓栓塞事件) 的风险.
- 脚手术对像APS这样的全身性疾病患者来说具有独特的挑战.
研究的目的:
- 评估抗脂综合征 (APS) 对足手术术术后结果的影响.
- 为了比较APS患者和对照组之间的血栓栓塞事件率和其他并发症.
主要方法:
- 使用TriNetX研究网络 (2004-2024) 的回顾性队列研究.
- 与APS患者 (有或没有静脉血栓塞栓症预防) 与对照者的匹配1:1比较.
- 对手术后30天和90天内结果的分析,包括血栓栓塞事件和贫血.
主要成果:
- 与对照组相比,接受VTE预防的APS患者的深静脉血栓发生率较高 (13.4%与9.0%相比),但中风/肺栓塞发生率相似.
- 接受VTE预防的APS患者在30天和90天出现显著较低的贫血率.
- 与对照组相比,没有抗凝药的APS患者的肺栓塞率较高 (5.8%vs3.3%).
结论:
- 抗脂综合征 (APS) 增加了脚手术后血栓栓塞事件的风险,即使使用抗凝药.
- 在APS患者中,抗凝药可能会降低术后贫血的发生率,这表明复杂的出血风险概况.
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