慢性腹和正常结肠镜检查患者随机结肠活检采样的诊断产量:系统性审查和元分析
Priyadarshini Loganathan1, Babu P Mohan2, Daryl Ramai2
1Department of Internal Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
iGIE : innovation, investigation and insights
|February 6, 2026
概括
随机结肠活检诊断出30%的慢性不明原因腹患者有显著的组织病理变化. 微观性结肠炎在15%的病例中被发现,在结肠镜检查正常时有助于诊断.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 内部医学 内部医学
背景情况:
- 大多数慢性不明原因腹的结肠镜检查显示没有异常.
- 常规的随机结肠活检是进一步诊断评估的标准.
- 在这种情况下,随机活检采样的诊断价值需要澄清.
研究的目的:
- 系统地审查和元分析随机结肠活检采样的诊断产量.
- 为了确定结合的诊断值在患者与正常的结肠镜检查结果和慢性腹.
主要方法:
- 评估随机活检采样研究的系统审查和元分析.
- 在MEDLINE,Scopus和Embase数据库中搜索到2022年5月.
- 使用随机效应模型并使用I2统计数据评估异质性.
主要成果:
- 包括21项研究,涉及3322名患者.
- 有意义的组织病理学变化的汇总率为30% (95% CI,20-41%).
- 微观性结肠炎被诊断为15% (95% CI,10-21%),淋巴细胞性结肠炎为9%,质结肠炎为3.5%.
结论:
- 随机结肠活检显示,30%的患者有显著的组织病理变化.
- 微观性结肠炎是15%的病例中发现的关键诊断.
- 在48%的患者中,发生了正常结肠活检采样.
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