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化疗后的转化手术在IV期BRAF中V600E突变的横向扩散瘤与神经内分泌成分

Reona Kawamura¹, Naoya Toyoshima¹, Masau Sekiguchi¹

¹Endoscopy Division National Cancer Center Hospital Tokyo Japan.

|February 6, 2026

概括

这项罕见的案例研究表明,对于具有神经内分泌癌症的IV期BRAF V600E突变结直肠癌的成功转化手术. 化疗使瘤回归,允许手术切除,并导致两年无复发的结果.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
手术瘤学手术瘤学

背景情况:

横向扩散的瘤 (LST),颗粒型 (LST-G),是结直肠瘤的一种亚型.
神经内分泌癌 (NEC) 是一种罕见的恶性瘤,可以发生在结直肠中.
BRAF V600E突变与侵袭性结直肠癌和不良预后有关.

研究的目的:

在第四阶段结直肠癌中报告一种罕见的LST-G与NEC成分的病例.
为了评估系统化疗和转换手术在这种特定患者形状中的疗效.
突出多式治疗在治疗混合组织学和BRAF突变的晚期结直肠癌中的潜在作用.

主要方法:

一个患有第四期结肠直肠癌的患者的病例报告.
系统化疗,然后进行转换手术.
在治疗前后对瘤组织进行病理和分子分析.

主要成果:

这位患者出现了LST-G,NEC组件和远程转移.
系统化疗导致原发性和转移性病变的显著回归.
转换手术是成功的,病理分析显示只有腺癌和NEC组件的完全消失.
分子测试证实了BRAF V600E突变的持久性.
患者在手术后两年内仍然没有复发.

结论:

转换手术对于某些患有IV期BRAF V600E突变结直肠癌和NEC的患者来说可能是一个可行的选择.
多模式治疗,包括化疗和手术,可以在晚期结直肠癌中实现长期缓解.
化疗后NEC组件的完整病理反应表明对全身治疗的敏感性.

关键词:

这是一个BRAFBRAF.转换手术是转换手术.侧向扩散的瘤颗粒型 (LST-G)神经内分泌癌 (NEC) 是一种神经内分泌癌.系统化疗是一种全身化疗.

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