儿童不良经历及其对成年认知障碍的后续影响:系统性审查和元分析
Xin-Chao Wang1, Zhen-Peng Huang1
1Faculty of Nursing, Guangxi University of Chinese Medicine, Nanning, China.
Frontiers in psychiatry
|February 6, 2026
概括
童年不良经历,如童年创伤和情感疏忽,与成人认知障碍有关. 虽然有证据表明存在联系,但由于观察数据有限,因果关系仍然未被证明.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 认知障碍显著影响成年人的生活质量.
- 童年不良经历 (ACE) 可能对成年人的认知功能产生长期影响.
- 了解ACEs与认知障碍的联系对于公共卫生倡议至关重要.
研究的目的:
- 系统地审查和元分析ACE和成人认知障碍之间的关联.
- 综合现有关于各种形式的童年逆境和认知衰退之间的关系的证据.
- 为了确定源于生命早期的认知障碍的潜在风险因素.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行系统的文献搜索,截至2025年2月.
- 独立的选,数据提取和使用纽卡斯尔-太华尺度评估所包含研究的质量评估.
- 使用RevMan5.4.1进行的元分析,以聚合效应大小.
主要成果:
- 四项研究 (2个横截面,1个队列,1个病例控制) 被纳入了元分析.
- 儿童创伤问卷 (CTQ) 总分数升高 (MD=7.06,p=0.03) 和情绪疏忽 (MD=2.88,p=0.02) 与认知障碍有关.
- 在65岁以下的个体中,发现了显著的关联 (MD=2.59,p=0.04).
- 发表偏见是最小的建议,但受限于小数量的研究.
结论:
- 不良的童年经历显示出与认知障碍风险增加的潜在关联.
- 目前的证据,主要是从观察性研究中得出的证据,并不能确定确定的因果关系.
- 需要对强大的设计进行进一步的研究,以确认因果关系并探索潜在机制.
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