在患有肝硬化或不患肝硬化患者中修改EUS引导肝活检采样技术的充分性,安全性和技术决定因素:试点研究
Biswa Ranjan Patra1, Shashank Pujalwar1, Sidharth Harindranath1
1Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Mumbai, India.
iGIE : innovation, investigation and insights
|February 6, 2026
概括
这种经过修改的内镜超声导向肝活检 (EUS-LB) 技术在患有肝硬化或没有肝硬化的患者中安全地产生足够的组织用于诊断. 技术因素,如操作的数量和深度,显著影响样本大小.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 干预性内镜检查是干预性的内镜检查.
背景情况:
- 在EUS导向肝活检 (EUS-LB) 中影响样本产量的技术相关因素仍未得到充分研究.
- 评估EUS-LB的充分性,安全性和技术决定因素对于优化诊断产量至关重要.
研究的目的:
- 调查修改EUS-LB技术的充分性,安全性和技术决定因素.
- 评估技术相关因素对患有肝硬化和没有肝硬化的患者样本产量的影响.
主要方法:
- 采用了一种经过修改的EUS-LB技术,采用19尺法兰西尖针和湿肝吸.
- 组织获取涉及1-2次通过与可变的启动直到吸血,主要结果是组织充分性和组织学诊断.
主要成果:
- 在48/50的患者中获得了足够的样本,在49/50的患者中获得了最终的组织学诊断.
- 平均总样本长度 (TSL) 为7.98厘米,最长的样本长度 (LSL) 为1.89厘米.
- 没有观察到任何重大不良事件 (AEs) 和7个轻微的AEs (14%),这表明了有利的安全性.
结论:
- 修改后的EUS-LB技术提供了足够的组织获取,对肝硬化和非肝硬化患者都是安全的.
- 技术因素,特别是操作的数量和深度,是EUS-LB样本产量的关键决定因素.
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