在消化道内进行内镜下粘膜剖析后预防延迟出血的新型静血粘合剂粉末:美国首个多中心体验
Dennis Yang1, Amit Bhatt2, Maham Hayat1
1Center for Interventional Endoscopy, AdventHealth, Orlando, Florida, USA.
iGIE : innovation, investigation and insights
|February 6, 2026
概括
一种新型的静血粉,UI-EWD,在内镜下粘膜剖析 (ESD) 后预防延迟出血方面表现有前途. 这项研究发现,在消化道粘膜缺陷中UI-EWD应用时,延迟出血的发生率很低.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 血液静止 血液静止 血液静止
背景情况:
- 延迟出血 (DB) 是内镜下粘膜切割 (ESD) 后的一个显著并发症.
- 需要有效的策略来缓解术后出血风险.
- 一种新的静血粉末,UI-EWD (Nexpowder),被评估为防治DB.
研究的目的:
- 评估UI-EWD在预防ESD后延迟出血方面的疗效和安全性.
- 评估UI-EWD在各种胃肠道部位应用的技术成功.
主要方法:
- 在2023年1月至2024年3月期间接受ESD的83名患者的多中心回顾性分析.
- 用UI-EWD对ESD后的粘膜缺陷进行了应用,不包括内镜闭合的病例.
- 延迟出血被定义为在30天内需要住院治疗,输血或干预的出血.
主要成果:
- UI-EWD成功应用于所有粘膜缺陷,在97.6%的病例中技术成功.
- 观察到较低的延迟出血率 (3.6%),所有事件发生在24小时内,不需要重复干预.
- 没有报告任何穿孔病例; en bloc和R0切除率很高 (分别为96.2%和88.7%).
结论:
- UI-EWD很容易适用于整个肠道的ESD后粘膜缺陷.
- 初步数据表明,UI-EWD与ESD后延迟出血率较低有关.
- 需要进一步的比较研究来证实这些发现.
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