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Christopher Hakim¹, Aciel Shaheen², Ali Zakaria³

¹Department of Gastroenterology, Ascension Providence Hospital, Michigan State University College of Human Medicine, Southfield, Michigan, USA.

iGIE : innovation, investigation and insights

|February 6, 2026

概括

只有51%的医生建议在阳性多目标便DNA (MT-sDNA) 测试和阴性结肠镜检查后进行10年结肠直肠癌查后的随访. 老年患者和那些患有并发症的患者接受的时间间隔较短.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
预防医学预防医学

背景情况:

有组织的查计划显著降低了结直肠癌 (CRC) 死亡率.
多目标便DNA (MT-sDNA) 测试是一种FDA批准的CRC查工具,具有良好的合规性.
目前的指导方针建议在阳性MT-sDNA测试和阴性结肠镜检查后进行10年的随访,但做法各不相同.

研究的目的:

评估内镜学家对10年随访建议的频率.
为了确定影响随访间隔建议的因素,在阳性MT-sDNA测试和阴性结肠镜检查后.

主要方法:

在515名平均风险患者的回顾性分析中,在MT-sDNA测试阳性后接受了结肠镜检查.
排除标准包括先前的结肠镜检查,多,慢性肺炎史,IBD和低于最佳的结肠镜检查质量.
后勤回归分析了10年后续推的预测因素.

主要成果:

在MT-sDNA测试中观察到13%的错误阳性率.
在68名符合条件的患者中,结肠镜检查结果为阴性,51%的患者获得了10年随访建议.
老年患者和患有多种并发症的患者更有可能接受更短的查间隔 (≤5年).

结论:

只有不到一半的内镜医生坚持10年随访指南,对阴性结肠镜检测的MT-sDNA测试呈阳性.
患者的年龄和并发症等因素会影响更短的随访间隔,这可能与查的好处相矛盾.

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