儿童严重败血症:与急性损伤相关的流行病学和危险因素
Haibo Li1, Ying Zhang2, Hongyan Zhu1
1Department of Anesthesiology, Affiliated Chifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng Municipal Hospital, Chifeng, China.
Frontiers in pediatrics
|February 6, 2026
概括
患有急性损伤 (AKI) 的儿科严重败血症的发病率增加,但死亡率在2010-2019年期间下降. 早期识别儿童AKI风险因素对于改善结果至关重要.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 儿科严重败血症 (PSS) 是儿童死亡的主要原因.
- 急性损伤 (AKI) 显著影响PSS的严重程度和预后.
- 有限的数据存在于AKI风险因素和儿童败血症的结果.
研究的目的:
- 分析PSS患者 (2010-2019) 中的AKI发病率和结果的时间趋势.
- 确定与儿童败血症中AKI相关的危险因素.
- 评估AKI对医院内死亡率和医疗保健资源利用的影响.
主要方法:
- 美国国家住院样本 (NIS) 数据库 (2010-2019) 的回顾性分析.
- 包括被诊断患有严重败血症的儿童 (0-18岁).
- 在AKI和非AKI组之间比较结果 (死亡率,停留时间,成本);用于风险因素的多变量回归.
主要成果:
- 在PSS患者中的AKI发病率从2.7% (2010) 增加到8.0% (2019).
- 在研究期间,患有AKI的PSS的住院死亡率从32.40%降至17.90%.
- 在患有并发症的患者中,AKI更为常见,并且与较高的感染率有关.
结论:
- 越来越多的AKI认可和重症监护的进步可能解释了随着死亡率下降的发病率上升.
- AKI仍然是PSS严重程度的强有力的指标,死亡风险增加了七倍.
- 早期识别患有AKI风险的儿童对于改善生存至关重要.
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