在脊椎关节炎中骑自行车还是交换? 当前知识 当前知识
Sofia Karagianni1, Niki Kyriazi2, Nikolaos Michalakeas1
1Joint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Mediterranean journal of rheumatology
|February 6, 2026
概括
对于牛皮关节炎 (PsA) 和轴性脊椎关节炎 (axSpA),交换治疗 (交换) 或使用类似药物 (循环) 显示出类似的有效性. 像性别这样的患者因素可能会影响结果,因此需要进行风险评估.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮关节炎 (PsA) 和轴性脊椎关节炎 (axSpA) 分享了诸如TNF抑制剂,抗IL-17和JAK抑制剂等治疗选择.
- 由于对初始b/tsDMARDs的反应不足,许多患者需要修改治疗.
- 治疗策略包括循环 (相同的药物类别) 或交换 (不同的药物类别).
研究的目的:
- 批判性地审查文学,比较PsA和axSpA的自行车与交换策略.
- 评估不同治疗修改方法在治疗PsA和axSpA方面的有效性.
- 为了确定影响PsA和axSpA患者治疗结果的因素,进行治疗变化.
主要方法:
- 在PubMed出版的文献的叙事审查,从创立到2025年6月.
- 关键词包括"牛皮关节炎"",轴性脊柱炎"",性脊柱炎"",非放射性轴性脊柱炎"和"骑自行车"",交换"",交换".
- 包括标准包括成年人群和英语语言研究.
主要成果:
- 对于PsA,循环和交换似乎同样有效,尽管患者和药物特定的变化可能存在.
- 对于axSpA,切换到第二个TNFi是可行的,但随着后续治疗,整体有效性可能会下降.
- 在这两种条件下,切换到不同的作用机制对于二次不响应者来说都是一个有效的策略.
结论:
- 循环和交换策略在PsA和axSpA中表现出相似的成功率.
- 患者的特征,如性别,可能会影响循环与交换的相对疗效.
- 建议对风险因素进行进一步评估,以优化PsA和axSpA的治疗策略.
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