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Updated: Feb 7, 2026

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低收入和中等收入国家母体和新生儿多药耐药性格兰氏阴性殖民分离物的分子相关性:系统性审查
Joycelyn A Dame1,2, Gabrielle Obeng-Koranteng2, Nathan L'Etoile3,4
1Department of Child Health, University of Ghana Medical School, Accra, Ghana.
Open forum infectious diseases
|February 6, 2026
概括
母亲的多药耐药格拉姆阴性 (MDR-GN) 殖民很少在低收入和中等收入国家 (LMICs) 的新生儿垂直传播. 由于关于这一关键问题的文献稀缺,需要进一步研究.
科学领域:
- 新生儿健康 新生儿健康
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 抗多药性格拉姆阴性 (MDR-GN) 败血症是低收入和中等收入国家 (LMICs) 新生儿死亡的主要原因.
- 从母亲向新生儿的MDR-GN垂直传播的程度仍然在很大程度上是未知的.
- 了解传播途径对于预防新生儿感染至关重要.
研究的目的:
- 系统地审查现有关于LMIC中母体和新生儿MDR-GN殖民分离物分子相关性的文献.
- 描述在母亲-新生儿二合体中MDR-GN垂直传播的流行率和程度.
- 确定有关MDR-GN在LMIC中传播的知识差距.
主要方法:
- 使用PubMed和Scopus数据库进行了系统的文献搜索.
- 研究是根据PRISMA指导方针进行选择的,重点是LMIC文献,报告了母亲-新生儿对MDR-GN一致性的分子证据.
- 十一项研究符合分析的纳入标准.
主要成果:
- 从LMICs的母亲-新生儿二中观察到大量的MDR-GN殖民,采样方法有相当大的差异.
- 分子分析很少表明母亲和新生儿MDR-GN分离物之间的相关性,这表明垂直传播有限.
- 证据经常指向新生儿环境中的水平传播作为更常见的途径.
结论:
- 从母亲向新生儿的MDR-GN垂直传播在LMIC中似乎不常见.
- 目前关于这个主题的文献有限.
- 进一步的研究是必不可少的,以充分理解和解决MDR-GN在LMICs内新生儿的传播动态.
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