在博茨瓦纳艾滋病毒感染者中,社区殖民化与扩展频谱化素耐药肠道细菌的风险因素
Bogadi Loabile1,2,3, Ebbing Lautenbach1,2,4, Naledi Mannathoko5
1Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Open forum infectious diseases
|February 6, 2026
概括
艾滋病毒感染者 (PLWH) 中的扩展频谱素耐药肠道细菌 (ESCrE) 殖民与最近住院和家庭成员殖民有关. 在COVID-19封锁后观察到更低的患病率,这表明有保护因素.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 撒哈拉以南非洲的艾滋病毒感染者 (PLWH) 面临着关于扩展频谱氨酸耐药肠道细菌 (ESCrE) 的研究缺口.
- 了解非住院PLWH的ESCrE殖民负担和风险因素对于有针对性的干预至关重要.
研究的目的:
- 确定与非住院艾滋病毒感染者 (PLWH) 的ESCrE定居相关的风险因素.
主要方法:
- 从博茨瓦纳的一个监测队列中,对546名非住院成年PLWH进行了二次数据分析.
- 用ESCrE识别进行直肠抽样.
- 两变量和多变量分析以确定ESCrE殖民的风险因素.
主要成果:
- 27.3%的参与者对ESCrE直肠定居的查结果呈阳性.
- 对于ESCrE殖民的独立风险因素包括最近住院 (aOR: 3.37),家庭成员殖民 (aOR: 1.74) 和COVID-19封锁之前的招聘 (aOR: 2.01).
- 最近使用抗生素显示ESCrE殖民的几率比率升高非显著 (aOR:1.84).
结论:
- 最近住院和家庭ESCrE殖民是PLWH中ESCrE殖民的重要风险因素.
- 在COVID-19封锁后,ESCrE的流行率较低,这表明潜在的保护因素.
- 需要进一步的研究来了解这些保护作用的持续时间.
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