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Updated: Feb 7, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
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针对周心卫星DNA的有针对性的编辑改变了对介质驱动的敏感性

D G Eickbush, J Rahmat, M Lindsay

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    研究人员开发了一种CRISPR/Cas9方法来改变卫星DNA (satDNA) 阵列,特别是果中的响应器 (Rsp) 位点. 这种技术精确地修改了satDNA复制号,揭示了它对基因功能和基因组组织的影响.

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