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大脑性阿尔法病毒感染诱导PARP-1过度激活运动神经元中介的能量崩

Rodney Eric Williams, Lisa Pieterse, Swara S Patel

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    委内瑞拉马类脑炎病毒 (VEEV) 触发了多ADP-核糖) 聚合酶-1 (PARP-1) 的激活,导致能量耗尽和运动神经元死亡. 抑制PARP-1显示出保护神经元免受VEEV感染的前景.

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