相关实验视频

Updated: Feb 7, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

3.1K

一种替代DNA内核酶活动与LINE-1 ORF2编码的蛋白质有关

Mitsuhiro Nakamura, Huira C Kopera, Mark Dowling

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    长间隔元素-1 (L1) 逆转移子在它们的逆转录酶域内使用一种新的内核酶活性进行调动. 这种替代性内核酶 (alt-EN) 活性是保存的,并且可能使早期的逆转移素运动成为可能.

    更多相关视频

    Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage10:59

    Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

    Published on: August 21, 2021

    4.1K
    Substrate Generation for Endonucleases of CRISPR/Cas Systems11:53

    Substrate Generation for Endonucleases of CRISPR/Cas Systems

    Published on: September 8, 2012

    28.0K

    相关概念视频

    From DNA to Protein03:06

    From DNA to Protein

    The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
    22.4K
    Non-LTR Retrotransposons03:18

    Non-LTR Retrotransposons

    As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
    13.4K
    Alternative RNA Splicing02:18

    Alternative RNA Splicing

    Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
    There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
    25.2K
    DNA-only Transposons02:57

    DNA-only Transposons

    DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
    The donor site from where the transposon is excised is either degraded or...
    17.5K
    Recombinant DNA01:09

    Recombinant DNA

    Overview
    103.3K
    Encoding01:19

    Encoding

    Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
    Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
    867