在成年人一生中,频率解析的皮质功能连接性
bioRxiv : the preprint server for biology
|February 6, 2026
概括
随着年龄的增长,大脑的连接性会发生变化,α波段会减少,而delta,theta和gamma波段会增加. 贝塔频段连接在中年达到顶峰,影响感觉运动功能.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 衰老研究研究 衰老研究
背景情况:
- 人类大脑的功能取决于功能网络中的同步的神经元活动.
- 功能连接的障碍与大脑疾病有关,但健康的与年龄相关的变化尚未得到充分理解.
- 关于功能性大脑连接的年龄相关变化的行为相关性的证据有限.
研究的目的:
- 研究休息状态功能连接 (rs-FC) 在健康的成年人一生中如何演变.
- 为了识别频率特定的振荡同步的与年龄相关的变化.
- 探索这些与年龄相关的rs-FC变化对感觉运动功能的行为相关性.
主要方法:
- 利用了576名年龄在18~87岁的健康成年人的磁脑电图 (MEG) 记录.
- 分析了不同频段 (delta,theta,alpha,beta,gamma) 的静止状态功能连接 (rs-FC).
- 与传感动力衰减的测量相关的rs-FC变化.
主要成果:
- 观察到皮质rs-FC的广泛,频率特定的与年龄相关的变化.
- 随着年龄的增长,阿尔法波段的rs-FC下降;三角波段的rs-FC增加.
- 贝塔频段rs-FC显示出非线性模式,在中年达到顶峰,并且与感觉运动功能有关.
- 观察到rs-FC模式和振荡功率变化之间的差异.
结论:
- 健康的大脑衰老涉及功能性大脑网络的动态,频率特定的改变.
- rs-FC的变化是可以将其与振荡功率的变化分开的.
- 改变的β频 rs-FC具有行为相关性,影响老年人的感觉运动整合.
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