Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Dreaming01:30

Dreaming

519
Sigmund Freud revolutionized our understanding of dreams by proposing that they are a window into the unconscious mind. According to Freud, dreams are not mere stories our minds create while we sleep but are profoundly meaningful narratives about our hidden desires and fears. He introduced two key concepts: manifest content and latent content. The manifest content is the actual content and imagery of the dream — what we remember when we wake up. The latent content, however, represents the...
519
Lucid Dreaming01:10

Lucid Dreaming

570
Lucid dreaming is a unique state of consciousness where an individual realizes they are dreaming while still in the dream. This awareness allows them to manipulate their dream environment consciously. Researchers like Stephen LaBerge have significantly contributed to the understanding of lucid dreams, highlighting that during these dreams, certain areas of the brain, such as the prefrontal cortex, that involve self-awareness and thought evaluation show increased activity.
Studies have shown...
570
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

9.9K
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
9.9K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Spatiotemporal Transcriptomic Dissection Uncovers Age-Dependent Deceleration of Esophageal Cell Differentiation.

bioRxiv : the preprint server for biology·2026
Same author

Comparative single-cell transcriptomics of orthotopic and subcutaneous gastric tumors reveal immune and stromal heterogeneity.

bioRxiv : the preprint server for biology·2026
Same author

SMARCA4 Loss Promotes Late-Stage Tumor Progression in Nonneuroendocrine Small Cell Lung Cancer.

Molecular cancer research : MCR·2026
Same author

Dose-Response Relationship of Niclosamide and Metformin Combination in Apc<sup>Min/+</sup> Mice: An Integrated <i>In Vivo</i> and Pharmacokinetic Modeling Study.

Gut and liver·2025
Same author

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer.

Nature communications·2025
Same author

Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics.

Proceedings of the National Academy of Sciences of the United States of America·2025

相关实验视频

Updated: Feb 7, 2026

Transduction of Human Cells with Polymer-complexed Ecotropic Lentivirus for Enhanced Biosafety
14:03

Transduction of Human Cells with Polymer-complexed Ecotropic Lentivirus for Enhanced Biosafety

Published on: July 24, 2011

15.7K

NFATc3 增强了 DREAM 复杂驱动的交易激活功能

Jieun Ahn, Yoojeong Seo, Jinho Jang

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    激活T细胞的核因子 (NFAT) 转录因子,特别是NFATc3,通过激活DREAM目标基因,意外地促进了肺腺癌 (LUAD) 细胞的增殖. 向-NFATc3通路为LUAD提供了一个新的治疗策略.

    科学领域:

    • 分子生物学分子生物学
    • 细胞生物学 细胞生物学
    • 癌症研究 癌症研究

    背景情况:

    • 激活T细胞核因子 (NFAT) 转录因子调节细胞过程,但它们在瘤细胞中的作用尚不清楚.
    • 梦想复合体控制细胞静止和增殖.
    • 肺腺癌 (LUAD) 细胞增殖机制需要进一步阐明.

    研究的目的:

    • 为了研究NFAT转录因子在LUAD中的作用.
    • 确定用于LUAD治疗的新型分子标.
    • 探索信号,NFAT和LUAD中的DREAM复合体之间的相互作用.

    主要方法:

    • 在LUAD细胞中对NFAT成员表达的分析.
    • 研究NFATc3对于LUAD细胞增殖和DREAM目标基因交换活化的要求.
    • 染色体免疫沉以评估DREAM目标促进者的NFATc3丰富.
    • 同免疫沉研究NFATc3与DREAM复合体的关联.

    主要成果:

    • NFATc3主要表达在LUAD细胞中,对LUAD细胞增殖至关重要.
    • 对于DREAM的目标基因交换激活,NFATc3是必要的.
    • NFATc3局部化到DREAM目标促进体,并与DREAM复合体相互作用,可能通过LIN9.

    更多相关视频

    Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes
    06:36

    Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes

    Published on: July 28, 2017

    12.5K
    Light-driven Enzymatic Decarboxylation
    09:58

    Light-driven Enzymatic Decarboxylation

    Published on: May 22, 2016

    12.3K

    相关实验视频

    Last Updated: Feb 7, 2026

    Transduction of Human Cells with Polymer-complexed Ecotropic Lentivirus for Enhanced Biosafety
    14:03

    Transduction of Human Cells with Polymer-complexed Ecotropic Lentivirus for Enhanced Biosafety

    Published on: July 24, 2011

    15.7K
    Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes
    06:36

    Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes

    Published on: July 28, 2017

    12.5K
    Light-driven Enzymatic Decarboxylation
    09:58

    Light-driven Enzymatic Decarboxylation

    Published on: May 22, 2016

    12.3K

    结论:

    • 在LUAD中,NFATc3在促进DREAM目标基因交换活化方面发挥了意想不到的作用.
    • -NFATc3轴是LUAD中潜在的分子标.
    • 在LUAD中,DREAM复合体的激活丰富了-NFATc3通路.