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Updated: Feb 7, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
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Published on: May 2, 2018

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一个活性-抵抗权衡限制了酶进化的进化

Alexander W Sarkis, Jens Laurids Sørensen, Teis Esben Sondergaard

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    产生抗生素的真菌通过与酶效率的权衡,对酸 (MPA) 进化了自我抵抗力. 对利巴维林-5'-单酸盐 (RVP) 已经存在的耐药性可能为MPA耐药性铺平了道路.

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