城市化的不同轨迹塑造了整个南亚的人类肠道微生物群
bioRxiv : the preprint server for biology
|February 6, 2026
概括
人类肠道微生物群在南亚社区之间有很大差异,受地理因素的影响比生活方式的影响更大. 城市化改变了微生物组,但应对措施是特定于社区的,这凸显了对量身定制的健康方法的需求.
科学领域:
- 微生物组研究的研究.
- 人类生态人类生态学
- 人口遗传学 人口遗传学
背景情况:
- 人类肠道微生物群适应生活方式的变化,但不同文化的保护尚不清楚.
- 了解这些适应对于公共卫生和个性化医学至关重要.
研究的目的:
- 为了研究肠道微生物群对不同南亚人群生活方式转变的反应.
- 为了比较不同社区的祖先村庄和城市中心的微生物组合.
主要方法:
- 在575名成年人中进行了人口规模的16S rRNA基因测序研究 (南亚微生物组ARray - SAMBAR).
- 抽样参与者来自十个地理和社会文化多样化的南亚社区,在农村和城市环境中.
- 分析了微生物组的组成,并将其与地理,社区成员资格和生活方式因素相关联.
主要成果:
- SAMBAR微生物组表现出独特的组成模式,与地理和社区的联系比生活方式更强烈,与全球队列不同.
- 城市化持续增加了与疾病相关的种类,但微生物群适应生活方式的变化是社区特有的.
- 在一些社区观察到小麦和乳制品相关的微生物模块的获取,可能有助于适应乳糖不持久性.
- 微生物群对城市化反应显示出明显的异质性,即使在区域内,受到当地文化和地理的影响.
结论:
- 肠道微生物群对城市化和生活方式变化的反应在南亚社区中高度异质.
- 在这种情况下,地理位置和社区成员资格是微生物组组成的强大驱动力,而不是生活方式.
- 未来的卫生干预措施必须考虑社区特定的微生物群概况,因为局部适应模式.
相关概念视频
Orthogonal Trajectories
70
Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
70
Molecular Shape and Polarity
75.8K
Dipole Moment of a Molecule
75.8K
VSEPR Theory and the Basic Shapes
85.2K
Overview of VSEPR Theory
85.2K
Molecular Shapes
62.2K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
Two regions of electron density in a diatomic...
62.2K
First Derivatives and the Shape of a Graph
86
In calculus, the concept of the first derivative plays a crucial role in understanding the behavior of a function over its domain. The first derivative, denoted as f’(x), provides insight into how a function changes at any given point, much like a cyclist adjusting speed along a winding trail. By analyzing the first derivative, mathematicians can determine where a function is increasing, decreasing, or reaching critical points.The first derivative provides a precise method for classifying...
86
Second Derivatives and the Shape of a Graph
108
The second derivative of a function provides essential information about a graph's curvature and how it changes over an interval. It helps determine whether a function is concave upward or concave downward and identifies points where the curvature changes. These properties are fundamental in analyzing real-world scenarios, such as changes in road elevation, population growth, and economic trends.A function f(x) is considered concave upward on an interval if its graph lies above all its tangent...
108


