Smad1/5/8的CRISPR介导条件突变发生揭示了BMP/GDF信号限制了出生后骨过度生长

概括

一个新的CRISPR/Cas9系统条件突变了BMP/GDF信号效应器Smad1,Smad5和Smad8. 这导致了产后骨强,揭示了在骨质母细胞调节中恒温的作用.

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