微生物组衍生代谢物在慢性HIV-1感染中形成CD4+T细胞分化和免疫衰老
bioRxiv : the preprint server for biology
|February 6, 2026
概括
肠道细菌代谢物对艾滋病毒-1 (PLWH) 感染者的CD4+T细胞功能产生影响. 与细胞相关的芳香性肠道衍生细菌代谢物 (GDBM),如p-cresol硫酸盐 (PCS),驱动免疫衰老,并与HIV-1持久性有关.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 微生物组与宿主之间的相互作用
- 艾滋病毒-1病原体的产生.
背景情况:
- 肠道衍生细菌代谢物对免疫细胞代谢的影响还未得到充分研究.
- 携带HIV-1 (PLWH) 感染者表现出免疫细胞功能的改变.
研究的目的:
- 调查芳香性肠导细菌代谢物 (GDBMs) 在塑造PLWH中CD4+T细胞代谢和功能的作用.
- 探索GDBMs,免疫衰老和HIV-1储存体大小之间的联系.
主要方法:
- 来自PLWH的血和CD4+T细胞的ex vivo代谢分析.
- 流细胞计和CD4+T细胞的单细胞RNA测序.
- 在GDBM暴露的CD4+T细胞的体外转录和蛋白质组分析.
- 测量HIV-1储大小的方法.
主要成果:
- 与细胞相关的芳香性GDBMs,特别是p-cresol硫酸盐 (PCS),显著改变了CD4+T细胞代谢和功能.
- PCS暴露诱导了CD4+T细胞衰老,差异化受损,并促进了类似监管的状态.
- 与GDBMs相关的CD4+T细胞状态与PLWH中完整的前病毒DNA水平相关.
结论:
- 一个涉及GDBMs的微生物群衍生轴重塑CD4+T细胞代谢,促进PLWH中的免疫衰老.
- 这些GDBM诱导的免疫代谢状态可能会导致长期的HIV-1储库持久性.
相关概念视频
First Derivatives and the Shape of a Graph
86
In calculus, the concept of the first derivative plays a crucial role in understanding the behavior of a function over its domain. The first derivative, denoted as f’(x), provides insight into how a function changes at any given point, much like a cyclist adjusting speed along a winding trail. By analyzing the first derivative, mathematicians can determine where a function is increasing, decreasing, or reaching critical points.The first derivative provides a precise method for classifying...
86
Second Derivatives and the Shape of a Graph
108
The second derivative of a function provides essential information about a graph's curvature and how it changes over an interval. It helps determine whether a function is concave upward or concave downward and identifies points where the curvature changes. These properties are fundamental in analyzing real-world scenarios, such as changes in road elevation, population growth, and economic trends.A function f(x) is considered concave upward on an interval if its graph lies above all its tangent...
108
Humoral Immune Responses
84.0K
Overview
84.0K
What is the Immune System?
130.5K
Overview
130.5K
Molecular Shape and Polarity
75.8K
Dipole Moment of a Molecule
75.8K
VSEPR Theory and the Basic Shapes
85.2K
Overview of VSEPR Theory
85.2K


