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Updated: Feb 7, 2026

A Drosophila Model to Study Wound-induced Polyploidization
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Published on: June 9, 2020

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独特的p21动态驱动了通过共同的CDK4/6-依赖多倍体G0状态实现全基因组重复的替代途径

Yian Yang, Anuraag Bukkuri, Dante Poe

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    在癌症中,全基因组复制 (WGD) 可能由不同的p21蛋白水平引发,导致治疗耐药性. 用抑制剂阻止CDK4/6活动可以防止WGD和瘤进化.

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