脱发瘤脂肪细胞比例和高度血清性卵巢癌存活率
bioRxiv : the preprint server for biology
|February 6, 2026
概括
瘤脂肪细胞含量增加与高度血清性卵巢癌 (HGSOC) 的生存率降低有关. 这一发现可能会改善风险分层,并指导针对HGSOC患者脂肪细胞的新疗法.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 基因组学就是基因组学.
背景情况:
- 高度血清性卵巢癌 (HGSOC) 的单细胞分析忽略了脂肪细胞,这是关键的瘤微环境组件,通常在转移性部位 (如体) 中发现.
- 脂肪细胞,尽管它们的脆弱性和单细胞数据中的代表性不足,在癌症进展中发挥着积极的作用.
研究的目的:
- 调查内脂肪细胞分数与HGSOC的整体存活率之间的联系.
- 评估脂肪细胞和其他细胞类型 (免疫细胞,肌细胞,上皮细胞) 对HGSOC患者结局的影响.
主要方法:
- 通过结合脂肪和HGSOC数据,创建了一个复合单细胞参考.
- 来自588个HGSOC瘤 (希尔德克劳特队列) 的大量RNA-seq数据使用复合参考进行了解卷.
- 用阶段分层的Cox模型来分析脂肪细胞分数与整体存活率之间的关系,并调整临床共变量.
主要成果:
- 估计瘤脂肪细胞含量增加10%与死亡风险增加41%相关 (HR=1.41,p=0.0002).
- 免疫细胞比例增加与有利的存活率相关 (HR=0.82,p=0.024),而树皮和上皮部分没有显著的关联.
- 在对其他细胞类型和残留疾病进行调整后,这些关联保持一致.
结论:
- 脂肪细胞代表了一个潜在的瘤内在因素,与HGSOC的不良结果相关.
- 通过大量RNA-seq量化量化脂肪细胞负担可以提高HGSOC患者的风险分层.
- 这些发现可能有助于开发针对HGSOC.HGSOC的新型脂细胞向治疗策略.
更多相关视频
07:19Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
Published on: January 6, 2023
5.3K
08:17Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
Published on: December 9, 2016
11.3K
相关概念视频
Sample Proportion and Population Proportion
6.8K
Collecting samples or responses from an entire population takes significant time and effort, so a researcher collects responses from only a sample of that population. Suppose a study needs to collect information about a specific mobile application. After sample collection, the researcher analyzes the data and discovers that most individuals in the sample use that specific mobile application. The sample proportion measures the number of individuals in a sample who either use or don't use the...
6.8K
Testing a Claim about Population Proportion
4.0K
A complete procedure for testing a claim about a population proportion is provided here.
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
4.0K
Graded Potential
7.1K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.1K
Survival Curves
721
Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
721
Survival Tree
433
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
Building a Survival Tree
Constructing a...
Building a Survival Tree
Constructing a...
433
Types of Aggregate Grading
1.5K
Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
1.5K
