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Updated: Feb 7, 2026

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卵巢激素缺乏症通过转录和代谢变化增强木烟引起的免疫功能障碍
bioRxiv : the preprint server for biology
|February 6, 2026
概括
卵巢激素缺乏会通过破坏骨髓免疫细胞增加对野火烟雾 (WS) 的敏感性. 缺乏木烟的小鼠暴露在木烟中重新编程了巨细胞,改变了免疫反应和新陈代谢.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 野火烟雾 (WS) 的暴露正在增加,对公众健康构成风险.
- 卵巢激素缺乏是WS诱导的免疫效应的潜在易感因素.
- 了解这些相互作用对于风险评估至关重要.
研究的目的:
- 为了研究卵巢激素缺乏如何影响免疫细胞对木烟 (WS) 暴露的反应.
- 在卵巢切除 (OVX) 的背景下,识别受WS影响的特定免疫细胞群和途径.
- 探索WS暴露对巨细胞的功能和代谢后果.
主要方法:
- 来自暴露于过空气 (FA) 或WS的OVX小鼠骨髓免疫细胞的单细胞RNA测序.
- 从OVX和Sham操作的小鼠中对骨髓衍生巨细胞 (BMDM) 的功能性测试.
- 对转录程序,免疫细胞组成和巨细胞代谢的分析.
主要成果:
- 在OVX小鼠中,WS暴露抑制了免疫通路 (抗原处理,白细胞激活,抗病毒防御) 并改变了免疫细胞组成.
- 在OVX小鼠中,WS诱导的巨细胞重编程显示了在没有M1/M2极化的情况下的代谢转变 (增加氧化酸化和糖解).
- 这些影响是特定于OVX环境的,Sham小鼠表现出不同的反应.
结论:
- 卵巢激素缺乏会加剧骨髓中WS诱导的免疫干扰.
- 在卵巢激素缺乏的情况下,WS暴露会在巨细胞中触发独特的免疫代谢重编程.
- 激素状况是评估空气污染风险的关键因素,特别是来自野火烟雾.
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