用连续时间加权的动态贝叶斯网络揭示动态神经信息流
bioRxiv : the preprint server for biology
|February 6, 2026
概括
本研究介绍了连续时间加权的动态贝叶斯网络 (CTwDBN),用于绘制神经系统中的动态信息流. CTwDBN能够平稳地揭示时间变化的依赖性,优于分析复杂大脑活动的传统方法.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 网络科学 网络科学
背景情况:
- 了解神经信息流是至关重要的,但由于大脑网络的动态性质,这是具有挑战性的.
- 传统方法通常假定静态网络,无法捕捉实时交互.
- 现有的模型与神经连接的平稳的时间变化动态作斗争.
研究的目的:
- 引入连续时间加权的动态贝叶斯网络 (CTwDBN) 作为一个新的框架.
- 开发一个非静止图形模型,以揭示神经数据中的时间变化的条件依赖性.
- 在合成和真实电生理记录中分析动态信息流.
主要方法:
- 开发了连续时间加权的动态贝叶斯网络 (CTwDBN) 框架.
- 在合成数据集上验证了CTwDBN,以评估其在恢复基准信息流中的准确性.
- 将CTwDBN应用于来自指导跳动任务和静止状态fMRI数据的电生理学记录.
主要成果:
- CTwDBN准确地恢复了合成数据中的信息流的结构和动态.
- 对电生理学记录的分析揭示了皮质网络依赖的时间波动,持续时间比受体场动态更长.
- CTwDBN在一个低维依赖空间内发现了静态皮质网络的持续波动.
结论:
- CTwDBN是一种多功能工具,用于分析神经系统中的动态信息流.
- 该框架顺利捕捉了传统静态模型错过的时间变化的条件依赖关系.
- CTwDBN对于需要动态网络分析的复杂生物和人工系统具有广泛的适用性.
相关概念视频
Dynamic Equilibrium
63.0K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.0K
Basic Continuous Time Signals
706
Basic continuous-time signals include the unit step function, unit impulse function, and unit ramp function, collectively referred to as singularity functions. Singularity functions are characterized by discontinuities or discontinuous derivatives.
The unit step function, denoted u(t), is zero for negative time values and one for positive time values, exhibiting a discontinuity at t=0. This function often represents abrupt changes, such as the step voltage introduced when turning a car's...
The unit step function, denoted u(t), is zero for negative time values and one for positive time values, exhibiting a discontinuity at t=0. This function often represents abrupt changes, such as the step voltage introduced when turning a car's...
706
Sampling Continuous Time Signal
755
In signal processing, a continuous-time signal can be sampled using an impulse-train sampling technique, followed by the zero-order hold method. Impulse-train sampling involves the use of a periodic impulse train, which consists of a series of delta functions spaced at regular intervals determined by the sampling period. When a continuous-time signal is multiplied by this impulse train, it generates impulses with amplitudes corresponding to the signal's values at the sampling points.
In the...
In the...
755
Continuous -time Fourier Transform
918
The Fourier series is instrumental in representing periodic functions, offering a powerful method to decompose such functions into a sum of sinusoids. This technique, however, necessitates modification when applied to nonperiodic functions. Consider a pulse-train waveform consisting of a series of rectangular pulses. When these pulses have a finite period, they can be accurately represented by a Fourier series. Yet, as the period approaches infinity, resulting in a single, isolated pulse, the...
918
Dynamics of Circular Motion
25.5K
An object undergoing circular motion, like a race car, is accelerating because it is changing the direction of its velocity. This centrally directed acceleration is called centripetal acceleration. This acceleration acts along the radius of the curved path (thus is also referred to as radial acceleration).
Any acceleration must be produced by some force. Therefore, any force or combination of forces can cause centripetal acceleration. A few examples include the tension in the rope on a...
Any acceleration must be produced by some force. Therefore, any force or combination of forces can cause centripetal acceleration. A few examples include the tension in the rope on a...
25.5K
Fermi Level Dynamics
735
The vacuum level denotes the energy threshold required for an electron to escape from a material surface. It is usually positioned above the conduction band of a semiconductor and acts as a benchmark for comparing electron energies within various materials.
Electron affinity in semiconductors refers to the energy gap between the minimum of its conduction band and the vacuum level and it is a critical parameter in determining how easily a semiconductor can accept additional electrons.
The work...
Electron affinity in semiconductors refers to the energy gap between the minimum of its conduction band and the vacuum level and it is a critical parameter in determining how easily a semiconductor can accept additional electrons.
The work...
735


