Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Language01:16

Language

918
Language is a unique communication system that uses words and systematic rules to organize and transmit information. Unlike other forms of communication, which may involve postures, movements, odors, or vocalizations, language relies on symbols and grammar. This makes human communication distinct from that of other species, who also communicate but do not use language in the same way humans do.
Corballis and Suddendorf (2007) and Tomasello and Rakoczy (2003) highlight the role of language in...
918
Genomics02:02

Genomics

40.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.8K
Components of Language01:24

Components of Language

821
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
821
Language Development01:22

Language Development

920
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
920
Language and Cognition01:27

Language and Cognition

804
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
804
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Bam-readcount - rapid generation of basepair-resolution sequence metrics.

Journal of open source software·2026
Same author

Automating neoantigen selection for personalized cancer vaccine design.

medRxiv : the preprint server for health sciences·2026
Same author

pVACtools v6: A comprehensive suite for neoantigen prediction, visualization, and therapy design.

ArXiv·2026
Same author

Case Report: Synchronous Manifestations of Kaposi Sarcoma Herpesvirus-Associated Disorders.

Cancer reports (Hoboken, N.J.)·2026
Same author

Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.

Nature cancer·2026
Same author

The GA4GH Categorical Variation Representation Specification: A Unified Computational Framework for Reasoning over Genomic Variant Categories.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Feb 7, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

使用大型语言模型搜索可用于药物的基因组.

Lars Schimmelpfennig, Matthew Cannon, Quentin Cody

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    我们开发了DGIdb模型上下文协议 (MCP) 服务器,使大型语言模型 (LLM) 能够访问药物基因相互作用数据. 这提高了使用药物基因相互作用数据库 (DGIdb) 的生物医学问题的LLM准确性.

    科学领域:

    • 生物信息学是一种生物信息学.
    • 计算生物学 计算生物学
    • 药物基因组学 药物基因组学

    背景情况:

    • 可使用药物的基因组包括与药物相互作用的基因.
    • 药物基因相互作用数据库 (DGIdb) 是药物基因相互作用的关键资源.
    • 目前的DGIdb访问需要结构化查询,限制自然语言的使用.

    研究的目的:

    • 为了使DGIdb.db的自然语言查询.
    • 将大型语言模型 (LLM) 与DGIdb集成,以提高生物医学知识的获取.
    • 提高药物基因相互作用数据的准确性和可访问性.

    主要方法:

    • 开发DGIdb模型上下文协议 (MCP) 服务器.
    • 促进LLM对DGIdbAPI的访问.
    • 通过自然语言查询来展示增强的LLM性能.

    主要成果:

    • 该MCP服务器允许LLM访问来自DGIdb.db的最新信息.
    • 通过使用MCP服务器来回答生物医学问题,LLM表现出更好的能力.
    • 在获取药物基因相互作用数据方面提高了准确性.

    更多相关视频

    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
    03:14

    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

    Published on: December 6, 2024

    1.2K
    Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
    06:16

    Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

    Published on: June 6, 2020

    4.6K

    相关实验视频

    Last Updated: Feb 7, 2026

    Pattern-based Search of Epigenomic Data Using GeNemo
    06:38

    Pattern-based Search of Epigenomic Data Using GeNemo

    Published on: October 8, 2017

    5.4K
    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
    03:14

    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

    Published on: December 6, 2024

    1.2K
    Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
    06:16

    Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

    Published on: June 6, 2020

    4.6K

    结论:

    • DGIdb MCP 服务器有效地将LLM和结构化生物医学数据库连接起来.
    • 这有助于更直观,更准确地获取药物基因相互作用信息.
    • 通过民主化数据访问,支持更广泛的研究和临床应用.