相关实验视频

Updated: Feb 7, 2026

Imaging Mismatch Repair and Cellular Responses to DNA Damage in Bacillus subtilis
10:28

Imaging Mismatch Repair and Cellular Responses to DNA Damage in Bacillus subtilis

Published on: February 8, 2010

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不匹配修复MLH复合体对复制后不匹配修复和三核酸重复扩张有明显的贡献

Katherine M Casazza, Greg M Williams, Lauren Johengen

    bioRxiv : the preprint server for biology
    |February 6, 2026
    PubMed
    概括

    酵母中的不匹配修复 (MMR) 途径使用MSH复合体来修复DNA错误. 不同的MLH复合体在标准MMR和CAG重复扩张中具有不同的作用,与疾病相关.

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    Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay10:32

    Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay

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    Application of Stopped-flow Kinetics Methods to Investigate the Mechanism of Action of a DNA Repair Protein11:01

    Application of Stopped-flow Kinetics Methods to Investigate the Mechanism of Action of a DNA Repair Protein

    Published on: March 31, 2010

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    相关概念视频

    Mismatch Repair01:36

    Mismatch Repair

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    Mismatch Repair01:20

    Mismatch Repair

    Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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    The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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    Overview of DNA Repair

    In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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    Nucleotide Excision Repair01:38

    Nucleotide Excision Repair

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    Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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    Long-patch Base Excision Repair

    Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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