头部和部肉瘤评估员 (HaNSA) 用现实世界的数据来做出治疗决策
概括
这项研究分析了亚洲人的头部和部瘤 (HNS),发现放射治疗相关的瘤影响结果. 一个新的预后计算器有助于预测HNS患者的整体存活率.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 头部和部肉瘤 (HNS) 是一种罕见的,多样化的癌症,存活率很低.
- 在亚洲人群中,HNS的研究不足,限制了临床试验的可行性.
- 在现实世界的亚洲队伍中,准确的组织学类型化对于理解HNS至关重要.
研究的目的:
- 分析头肉瘤的亚洲患者整体存活期 (OS) 的风险因素.
- 开发一个预后计算器来预测HNS患者的OS,使用现实世界的数据.
主要方法:
- 对275名经组织学证实HNS患者 (1985-2023) 的回顾性队列研究.
- 对OS风险因素的多变量考克斯回归分析.
- 参数时间到事件建模以创建预测计算器.
主要成果:
- 五年后的正常运行率为43.2%.
- 放射治疗相关的瘤发生在11.3%的患者中,与预后较差有关.
- 显微负 (R0) 切除边缘显著改善了OS;R1切除在特定情况下也显示出好处,特别是高剂量放射治疗.
结论:
- 呈现出最大的亚洲HNS队列,显示出部分由于放射治疗相关疾病导致的不良结果.
- 一个新的预后计算器展示了精选的真实世界数据的实用性,用于预测HNS等罕见癌症的OS.
相关概念视频
Arteries of the Head and Neck
3.3K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
3.3K
Veins of Head and Neck
5.6K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
5.6K
Decision Making
994
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
994
Muscles of the Anterior Neck
4.8K
The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
4.8K
Muscles that Move the Head
6.0K
The muscles that move the head are a dynamic and complex group of structures that work together to facilitate a wide range of head movements, including rotation, flexion, extension, and lateral bending.
The bilateral sternocleidomastoid, or SCM, and the suprahyoid and infrahyoid muscles are significant head flexors. The SCM muscles originate at the sternum and clavicle and attach to the mastoid process of the temporal bone. The SCM contracts bilaterally to bend the head forward, whereas...
The bilateral sternocleidomastoid, or SCM, and the suprahyoid and infrahyoid muscles are significant head flexors. The SCM muscles originate at the sternum and clavicle and attach to the mastoid process of the temporal bone. The SCM contracts bilaterally to bend the head forward, whereas...
6.0K
Decision Making: P-value Method
7.0K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
7.0K


