肝脏脆弱指数预测肝细胞癌系统治疗中的生存率:一个多中心前性队列研究
K M J Waller1,2,3, D S Prince4,5, E H Y Lai6
1AAW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown.
ESMO gastrointestinal oncology
|February 6, 2026
概括
通过肝脏脆弱指数 (LFI) 测量的脆弱性,可以独立预测接受全身治疗的晚期肝细胞癌 (HCC) 患者的死亡. 较高的LFI得分表明脆弱性增加,并与较差的生存结果有关.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 系统治疗改善了肝细胞癌 (HCC) 的存活率,但反应预测因子尚不清楚.
- 脆弱性对接受全身治疗的高级HCC患者的影响尚不清楚.
- 虚弱与肝硬化和肝移植的不良结果有关.
研究的目的:
- 研究在接受全身治疗的晚期HCC患者的脆弱性和结果之间的关联.
- 确定肝脏脆弱指数 (LFI) 是否可以预测这一群体的存活率.
主要方法:
- 一个国际性的,多中心的,前性的观察队列研究.
- 102名患有高级HCC的成年患者接受全身治疗 (2019-2022年).
- 使用肝脏脆弱指数 (LFI) 评估脆弱性;结果包括整体生存,进展,不良事件和停止治疗.
主要成果:
- 中位数LFI为4.13,其中22%被归类为脆弱 (LFI ≥4.5).
- 在对临床因素进行调整后,LFI独立预测死亡 (aHR 1.74,P=0.006).
- 虚弱与早期因功能衰退而停止治疗有关,而不是疾病进展或不良事件.
结论:
- 肝脏脆弱指数 (LFI) 是接受全身治疗的晚期HCC患者死亡率的独立预测指标.
- 脆弱性评估可能有助于优化治疗策略和预测HCC患者的结果.
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