在患有早期发病的局部晚期直肠癌的患者中,病理完整反应的比率更高
J Suarez1, M Alsina2,3, N Castro3
1Department of General Surgery, Hospital Universitario de Navarra (HUN), Pamplona.
ESMO gastrointestinal oncology
|February 6, 2026
概括
早发性直肠癌 (EORC) 正在上升,在2001年至2020年期间观察到的发病率增加. 尽管存活率相似,但EORC患者对化学放射治疗的病理完整反应率更高.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床研究 临床研究
背景情况:
- 结肠直肠癌的发病率正在下降,但早期结肠直肠癌 (EORC) 正在令人担忧地增加.
- EORC通常在晚期被诊断出来,并且可能具有独特的分子变化.
- 改善早期诊断和治疗策略对于管理EORC至关重要.
研究的目的:
- 分析局部晚期EORC患者对化学辐射疗法的特异反应.
- 为了比较EORC和晚发性直肠癌 (LORC) 患者之间的诊断和治疗反应变量.
- 为了评估EORC发病率的趋势.
主要方法:
- 对局部晚期直肠癌 (LARC) 患者的回顾性分析,这些患者接受了新辅助化学放射治疗 (NAT),随后进行了手术.
- 关于发病率,诊断变量和治疗反应的EORC和LORC队列的比较.
- 分析2001年至2020年间的发病率.
主要成果:
- 在2001年至2020年期间,局部发达EORC的发病率从6.6%增加到12.7%.
- 在EORC和LORC之间没有发现诊断变量的显著差异.
- 与LORC (12.4%) 相比,EORC患者的病理完整响应 (pCR) 率 (36.3%) 显著提高.
结论:
- 证实EORC的发生率正在增加.
- EORC患者表现出较高的pCR率,这表明可能存在器官保存策略.
- 对于这种独特的患者群体,对器官保存进行进一步的研究是有必要的.
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