产前PM2.5和重金属对早产的联合影响:来自中国嵌病例对照研究的证据
Jinxiu Feng1,2, Ziyi He1,3,4,2, Xin Ming1,3,4,2
1Women and Children's Hospital of Chongqing Medical University, China.
Frontiers in public health
|February 6, 2026
概括
产前暴露于细颗粒物 (PM2.5) 和重金属与早产 (PTB) 风险有关. 这项研究揭示了复杂的相互作用,强调了综合环境健康战略的必要性.
科学领域:
- 环境健康科学 环境健康科学
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 过早分娩 (PTB) 是一个重大的全球健康挑战.
- 产前暴露于细颗粒物 (PM2.5) 和重金属对PTB风险的综合影响需要进一步调查.
研究的目的:
- 调查孕期母亲暴露于PM2.5和18微量元素与早产风险之间的关联.
- 评估这些环境暴露对PTB的个体,混合和相互作用影响.
主要方法:
- 一个嵌套的病例控制研究,涉及111个PTB病例和124个对照.
- 测量母亲血液中微量元素度和估计家庭PM2.5暴露.
- 应用物流回归,WQS,GWQS和BKMR模型来评估暴露-PTB关系.
主要成果:
- 在怀孕中期增加的PM2.5暴露与更高的PTB风险有关.
- 特定的微量元素显示出不同的关联:,和与PTB正相关,而和与PTB相反相关.
- 混合模型表明与PM2.5和必需微量元素相关的PTB风险增加,条件必需微量元素的反向关联. 观察到PM2.5和基本微量元素之间的潜在相互作用.
结论:
- 产前暴露于PM2.5和重金属混合物与PTB风险有关,表明复杂和相互作用的影响.
- 这些发现强调了对多重环境暴露的综合评估的必要性.
- 综合方法和有针对性的公共卫生干预措施对于减轻母亲和儿童健康风险至关重要.
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