对患有缺血性中风的老年患者认知功能轨迹和影响因素的分析:一项前性的纵向研究
Xinhao Chen1, Chengxia Wei1, Danli Zhao1
1Department of Neurology, Shanghai University of Traditional Chinese Medicine Affiliated Shanghai Pudong New Area Guangming Hospital of Traditional Chinese Medicine, Shanghai, China.
Frontiers in aging neuroscience
|February 6, 2026
概括
老年缺血性中风患者表现出不同的认知轨迹. 年龄,中风特征和社会支持预测认知能力下降,指导个性化干预以获得更好的结果.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 公共卫生 公共卫生
背景情况:
- 在老年缺血性中风患者中定义认知功能轨迹对于早期识别那些有认知衰退风险的人来说至关重要.
- 关于中国老年缺血性中风患者认知轨迹的异质性及其原因的研究有限.
研究的目的:
- 确定中国老年缺血性中风患者独特的认知轨迹趋势.
- 评估导致这些认知轨迹的因素.
主要方法:
- 未来的纵向研究,使用经过验证的认知评估工具,在规定的时间间隔内进行.
- 潜变增长模型被用来识别不同的认知轨迹子组.
- 后勤回归分析了认知轨迹的基线预测因素.
主要成果:
- 确定了三个不同的认知轨迹组:高认知功能-缓慢下降 (51%),低认知功能-中间下降 (34%) 和低认知功能-快速下降 (15%).
- 认知功能的重要预测因素包括年龄,叶梗塞,血清同型半素,NIH中风量表得分和感知到的社会支持.
结论:
- 老年缺血性中风患者随着时间的推移表现出各种认知衰退模式.
- 基于个人的认知轨迹和影响因素的定制干预措施可以减轻认知衰退并提高生活质量.
相关概念视频
The Influence of Affect on Cognition
296
Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
296
The Influence of Cognition on Affect
221
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
221
Longitudinal Studies
533
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
533
Bioavailability: Influencing Factors
400
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
400
Longitudinal Research
13.4K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.4K
Factors Influencing Microbial Growth: pH
1.2K
Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.2K


