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儿童无肠综合征的长期结果 - 一项多中心研究
Elena Cernat1, Susan Hill2, Rachel Wood3
1Paediatric Gastroenterology Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
概括
没有肠道综合征 (NGS) 的儿童得益于亲肠道营养的进步而生存. 大多数人上学,显示出积极的长期结果和改善了这些年轻患者的生活质量.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肠道衰竭管理 肠道衰竭管理
- 父母肠道营养是一种营养.
背景情况:
- 极端短肠综合症,称为无肠综合症 (NGS),对儿科患者提出了重大挑战.
- 亲肠道营养 (PN) 和医疗保健的进步导致NGS儿童的生存率增加.
研究的目的:
- 描述诊断为NGS的儿童的人口特征.
- 评估儿童NGS患者的长期结果.
主要方法:
- 一份问卷被分发给英国儿科肠衰竭 (IF) 中心,以识别PN的NGS患者.
- 纳入标准包括婴儿和18岁以下的儿童,其小肠 (十二指肠加最多5厘米的阴肠) 和结肠的剩余量最小.
- 随访数据是在招聘后两年收集的.
主要成果:
- 在19个中心的379名家庭亲肠道营养 (HPN) 患者中,14人 (4%) 被确定为NGS.
- NGS的主要病因是中肠卷发 (64%),肠道缺血 (22%),结核性肠球炎 (7%),状状 (7%).
- 大多数患者 (93%) 在PN上保持稳定,其中一人在小肠移植后被断奶; 61%的人容忍了一些肠道营养,79%的人上学.
结论:
- 改善的PN和医疗保健改善了NGS儿童的长期存活率.
- 儿科NGS患者表现出积极的长期结果,包括上学和参与日常活动.
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