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综合高分辨率副本编号和扩散半球质瘤的组织分子分析,H3 G34突变体揭示了普遍的TP53异常

Jorge A Trejo-Lopez1, Cinthya Zepeda Mendoza1, Thomas M Kollmeyer1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Brain pathology (Zurich, Switzerland)
|February 6, 2026
PubMed
概括

扩散半球质瘤,H3 G34突变 (DHG-H3 G34) 瘤显示普遍TP53异常,包括17p时的副本中性异构性损失 (cnLOH). 这项综合分析揭示了这种中枢神经系统瘤类型的更广泛的遗传情景.

关键词:
罗罗 罗 罗 罗复制中立的复制中立.扩散性质瘤是一种扩散性瘤.基因组 H3 基因组 H3 基因组失去了异性性的损失.

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