不是所有的压力都是相同的:在小规模的生存社会中,心理社会压力因素和尿道皮质醇节奏之间的可变关联
Dominik C Jud1,2, Valerie Baettig1, Abigail E Colby1
1Institute of Evolutionary Medicine, University of Zürich, Zürich, Switzerland.
概括
不同的压力因素在Tsimane人群中不同影响下丘脑-垂体-上腺 (HPA) 轴. 粮食不安全与更高的皮质醇水平和更的日间坡度有关,而经济问题则显示出相反的趋势.
科学领域:
- 人类生理学 人类生理学
- 压力研究 压力研究
- 人类学是人类学.
背景情况:
- 脑下垂体-垂体-上腺 (HPA) 轴的调节失调与肥胖和糖尿病等不良健康结果有关.
- 对HPA轴功能的研究正在扩大,但很少有研究区分各种压力因素的影响.
- 没有先前的研究研究了差异性压力因素对HPA轴在小规模生计群体中的作用的影响.
研究的目的:
- 调查不同类型的压力因素如何影响玻利维亚的西马尼人中HPA轴活动.
- 检查特定压力因素 (粮食不安全,社会冲突,经济问题) 与HPA轴的功能,包括白天皮质醇节律之间的关系.
- 在传统的生计背景下,为HPA轴监管提供新的见解.
主要方法:
- 尿中皮质醇水平 (日间斜率) 测量了来自三个社区的129名成年Tsimane参与者.
- 一份问卷评估了文化相关的心理社会压力因素,包括粮食不安全,社会冲突和经济问题.
- 多级别贝叶斯多变量模型被用来分析压力因素得分和皮质醇水平之间的关联.
主要成果:
- 粮食不安全与较高的早晨皮质醇水平和更的白天斜率相关.
- 经济问题与较低的清醒皮质醇水平和较浅的白天斜坡有关.
- 较高的早晨皮质醇和更的斜坡也与更好的自我评估健康有关,尽管存在统计不确定性.
结论:
- 这项研究突出了生活社会中感知到的压力因素和白天皮质醇模式之间的复杂相互作用.
- 不同的压力因素与HPA轴活动和皮质醇节奏有着不同的关联.
- 建议使用更高分辨率采样进行进一步的纵向研究,以阐明这些复杂的关系.
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