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Updated: Feb 7, 2026

Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
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通过TFAM的小分子调制抑制干扰素信号传递

Dionisia Sideris1, Husan Lee1, Lyndsay Olson1

  • 1Astellas Pharmaceuticals Inc, Oncology Research, Cancer Biology, Cambridge, United States.

eLife
|February 6, 2026
PubMed
概括

研究人员开发了新的小分子调节器,可以激活线粒体转录因子A (TFAM). 这些化合物增加TFAM蛋白和线粒体DNA (mtDNA) 水平,通过减少炎症,为线粒体疾病提供治疗潜力.

关键词:
在TFAM中,我们可以使用TFAM.在cGAS-STING路径中.细胞生物学 细胞生物学人类 人类 人类 人类 人类 人类 人类干扰子的信号传递线粒体中的线粒体.这是线粒体DNA的DNA.小分子分子小分子

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