在早产阶段的肠道微生物群和代谢变化:与支气管肺功能失调的潜在关联
Chunfang Gu1, Mingzhao Han2,3, Xiuling Chen1
1Department of Pediatrics, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China.
Microbiology spectrum
|February 6, 2026
概括
改变的肠道细菌 (Bacteroidota) 和与氧化压力相关的链球菌增加可能预测早产婴儿的支气管肺功能障碍 (BPD) 风险,这表明早期基于肠道的干预措施.
科学领域:
- 新生儿微生物组研究
- 在早产婴儿的肠肺轴.
- 代谢药物和婴儿健康
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的一个主要并发症,早期诊断标志物有限.
- 肠道微生物组和代谢组的发展对于早产婴儿的健康至关重要,并且可能会受到干扰.
- 干扰与不良结果有关,包括BPD.
研究的目的:
- 描述早产婴儿肠道微生物和代谢特征的时间变化.
- 探索这些个人资料和BPD发展之间的关联.
- 为了确定潜在的BPD风险的早期生物标志物.
主要方法:
- 从早产婴儿的便样本的综合多组学分析.
- 时间肠道微生物和代谢轨迹的表征.
- 微生物丰富度和代谢物水平之间的相关性分析.
主要成果:
- 正常的肠道成熟显示了 Bacteroidota 的明显下降.
- 患有BPD的婴儿表现出早期枯竭和不规则的Bacteroidota.丰富.
- 增加的 estreptococcus 丰富度与提升的囊酸相关,这是氧化应激的标志物.
结论:
- 改变的细菌杆菌连续性和链球菌相关的氧化失衡表明,在BPD风险中存在早期肠道干扰.
- 肠道微生物组和代谢组可能是BPD病变发生的肺外贡献者.
- 这些发现支持早期风险评估和针对微生物组的干预措施,以预防BPD.
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