一个3D打印的易破裂的动脉瘤模型,用于评估内血管器件的安全性和有效性
Husain Sodawalla1, Mohammed Alnajrani1, Jesse Wells1
1Department of Mechanical Engineering, Northern Arizona University, Flagstaff, Arizona, USA.
概括
一个新的3D打印的巨型动脉瘤模型可预测地破裂,使内血管器件能够更好地测试. 这种体外模型允许准确评估动脉瘤的医疗器械治疗方法.
科学领域:
- 生物医学工程 生物医学工程
- 医疗器械开发 医疗器械开发
- 血管外科 血管外科
背景情况:
- 目前的体外动脉瘤模型缺乏材料特性,无法准确地测试内血管器件.
- 现有的模型无法复制巨型动脉瘤的机械不稳定性或可预测的破裂.
- 需要采用具有生物力学相关性质和可预测破裂时间的体外模型.
研究的目的:
- 开发一个3D打印的巨型动脉瘤模型,具有可预测的破裂特征.
- 用这种新型体外模型来测试内血管治疗的疗效.
- 模拟各种动脉瘤治疗的血液动力学效应.
主要方法:
- 创建了一个3D打印的巨型动脉瘤模型.
- 该模型经受到了模拟的生理条件,以观察破裂.
- 模拟包括流量转移器,合成血栓的流量转移器和液体栓塞治疗的流量转移器.
- 未经处理的对照进行并行进行比较.
主要成果:
- 3D打印模型在模拟生理条件下证明了可预测的破裂.
- 仅使用转流器处理:47 (±41) 分钟,对照组:54 (±30) 分钟 (p=0.36).
- 带有合成血栓的流量转移器:22 (±16) 分钟与控制器的19 (±10) 分钟相比 (p=0.71).
- 使用液体栓塞治疗的流量转移器:61 (±27) 分钟,对照组为35 (±17) 分钟 (p=0.16).
结论:
- 开发的体外模型允许预测动脉瘤破裂,以测试医疗器械的疗效.
- 进一步的研究将根据压力和流量优化破裂时间.
- 这些模型可以评估动脉瘤破裂风险和治疗后的位置.
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