用组合纳米粒子库方法阐明基于脂的纳米材料的输送过程的结构决定因素
Peiming Zhang1, Kena Zhang1, Heidi Qunhui Xie2
1Zhejiang Key Laboratory of Environment & Health of New Pollutants, School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
ACS applied materials & interfaces
|February 6, 2026
概括
脂结构显著影响纳米粒子的行为. 兹维特里克头组改善了准,而较短的链则增加了增强的纳米交付系统的循环时间.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 脂对纳米输送系统至关重要,但它们对纳米粒子行为的结构影响尚未完全理解.
- 了解脂结构与特性关系是设计有效的基于脂质的纳米粒子的关键.
- 目前的知识差距阻碍了纳米输送系统的优化,以实现有针对性和高效的药物输送.
研究的目的:
- 调查脂头组化学和酸链长度如何影响基于脂质的纳米颗粒的生理行为.
- 阐明控制蛋白质吸附,细胞吸收和体内生物分布的结构依赖机制.
- 通过对脂成分的系统修改,提供优化纳米输送系统的设计原则.
主要方法:
- 合成了12种脂涂层金纳米粒子 (Lip@AuNP) 配方的图书馆.
- 根据头组类型 (PA,PS,PC,PE) 和异形链长度 (6:0,12:0,18:0) 的不同纳米粒子配方.
- 在动物模型中评估了蛋白质吸附,细胞吸收 in vitro 和 in vivo 生物分布.
主要成果:
- 双胞胎细胞组 (PC,PE) 降低了补充蛋白的吸附,并增强了非细胞的选择性吸收.
- 基于脂质的纳米颗粒与zwitterionic头组显示在脏中的积累增加.
- 较短的异质链导致较高的血清蛋白质吸附,减少非选择性细胞吸收,并延长循环时间.
结论:
- 脂头组和酸链长度是纳米输送系统性能的关键决定因素.
- 定制脂结构可以调节蛋白质相互作用,细胞向和体内命运.
- 研究结果为设计基于脂质的先进纳米颗粒提供了实际指导,提高了治疗效率和向性输送.
更多相关视频
08:33Functionalization and Dispersion of Carbon Nanomaterials Using an Environmentally Friendly Ultrasonicated Ozonolysis Process
Published on: May 30, 2017
10.6K
12:31A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
15.7K
相关概念视频
02:33Combinatorial Gene Control
9.7K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.7K
01:30Information Processing Approach
586
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
586
02:41Chromatin Structure Regulates pre-mRNA Processing
8.2K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
8.2K
03:38Structure of Lipids
99.1K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
99.1K
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
212
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
212
01:10Antibody Structure
65.6K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.6K