基于0D模型的脉冲波形分析的可行性作为检测上升胸前大动脉动脉瘤增长的工具
Lily Watkins1, Kiley Irwin2, Hadi Wiputra2
1Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455.
Journal of biomechanical engineering
|February 6, 2026
概括
检测上升胸前动脉动脉瘤 (ATAA) 增长可能是可能的,使用在家脉冲波形分析. 这种非侵入性方法显示了早期检测和降低风险的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 医学诊断 医学诊断 医学诊断
背景情况:
- 上升胸前动脉动脉瘤 (ATAA) 具有很高的破裂风险,存活率低.
- 目前的监测方法 (CT,MRI) 涉及到频繁的医院访问,影响了遵守和成本.
- 对ATAA生长的非侵入性家庭监测是非常理想的.
研究的目的:
- 调查使用脉冲波形频率分析来检测ATAA半径和壁度变化的可行性.
- 探索一种潜在的非侵入性家庭方法来监测ATAA的进展.
主要方法:
- 开发了对曲血管进行校正的0D血流模型,并通过流体结构相互作用 (FSI) 模拟进行验证.
- 在理想化的ATAA几何学中分析出口压力波形的快速里叶变换 (FFT).
- 基于5年患者纵向扫描的FSI模拟的应用方法.
主要成果:
- ATAA大小的变化与输出压力波形的FFT的一致变化相关.
- 脉冲波形频率响应的可检测变化表明血管硬化和生长.
- 在理想化模型和患者特定的FSI模拟中观察到类似的趋势.
结论:
- 脉冲波形频率分析,可以通过表面度测量,显示了检测ATAA增长的潜力.
- 这种方法可以构成一个新的基础,在家监测系统的ATAA患者.
- 非侵入性监测可以改善患者的坚持,并促进及时的手术干预.
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