月经功能障碍与青少年女性肝酶升高有关:一项基于美国人口的研究
Sheila L Noon1, Lauren F Chun2, Gillian Mackay3
1Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California; University of California, San Diego School of Medicine, La Jolla, California.
概括
多囊性卵巢综合征的症状,如 amenorrhea 和 hyperandrogenism 与青少年女性的肝损伤 (ALT升高) 有关. 建议对与代谢功能障碍相关的脂肪性肝病 (MASLD) 进行早期查,即使没有肥胖.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 儿科健康 儿科健康
背景情况:
- 多囊卵巢综合征 (PCOS) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 在青少年中越来越多地被诊断出.
- 在这个年龄组中,PCOS指标与肝脏健康之间的关系尚不清楚.
研究的目的:
- 调查青少年女性的月经异常和高雄性异常是否与肝脏疾病风险增加有关.
- 为了确定PCOS标志性特征与高氨酸转移酶 (ALT) 和疑似MASLD之间的关联.
主要方法:
- 分析国家健康和营养检查调查数据 (2011-2020年) 对于1651名12-19岁的美国女性,至少经过2年的经期.
- 定义包括无月经 (12个月没有月经) 和生化超原体 (自由原体指数≥5).
- 升高的ALT (>22U/L) 和可疑的MASLD (升高的ALT+心脏代谢风险因子) 是主要结局,使用经过年龄,种族/种族和BMI百分位数调整的加权后勤回归来分析.
主要成果:
- 缺血病 (2.8%的患病率) 与ALT升高 (aOR 2.5) 的更高几率有关.
- 生物化学性高雄性也与ALT升高有关 (aOR 2.6).
- 胰岛素耐药性和ALT之间的关联在青少年中更为强烈. 升高的ALT甚至在正常BMI的青少年中也很普遍.
结论:
- 亚美诺雷亚和高雄性异位症是PCOS的关键特征,在青少年女性中,它们独立地与ALT升高和疑似MASLD有关.
- 这些发现凸显了在有月经功能障碍的年轻人中进行ALT查的必要性,无论BMI如何.
- 早期检测可以为处于危险阶段的青少年提供综合性内分泌-肝脏护理.
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